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J. Rahul, Dr. P. Arun*, P. Shailendra, S. Aditya, D. Neelesh and V. Koushal


Cyclodextrins are cyclic torus-shaped molecules with a hydrophilic outer surface and a lipophilic central cavity, which can accommodate a variety of lipophilic drugs. As a consequence of the inclusion process, many physicochemical properties such as solubility, dissolution rate, stability and bioavailability can be fabourably modulated. Cyclodextrins have been receiving increasing application in pharmaceutical formulations in recent years due to their approval by various regulatory agencies. However, the use of cyclodextrins in solid oral dosage forms is limited to low dose drugs with large stability constants due to the mass limitations of oral dossage units. cyclodextrins is relatively simple and involves treatment of ordinary starch with a set of easily available enzymes. Commonly cyclodextrin glycosyltransferase (CGTase) is employed along with α-amylase. First starch is liquified either by heat treatment or using α-amylase, then CGTase is added for the enzymatic conversion. CDs has been used in pharmaceutical technology for many years as solubilizing agent. The solubility of poorly soluble drug can be achieved in many ways, such as modification of drug crystal forms, addition of cosolvents, addition of surfactants, addition of cyclodextrins, etc. Among the possibilities, the cyclodextrin approach is of particular interest. The first is the use of CDs, which present a higher solubility in water. The second method consists in adding a water-soluble polymer, like PVP, and HPMC, with the aim to increase the aqueous solubility of both the complex and the drug itself.

Keywords: Norflxacin, Cyclodextrins, PEG 4000/6000, HPMC.

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