WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



V. V. Dudhabale*, M. T. Mohite and K. V. Chandgude


Cancer is described as the uncontrolled growth of abnormal cells. The outcome of anticancer therapy is chiefly depending upon electivity of targets. Many targets for the treatment of cancer cells are available namely stem cells, protein coupled receptors, ErbB receptors, growth factor, fibroblast growth factor. The protein ligand interactions play a significant role in structural steroid hormones, proteases, protein kinase, vascular endothelial growth factors, transforming based drug designing. In our present research work, we have chosen Angiogenin, vascular endothelial growth factors, transforming growth factors, fibroblast growth factor as targets to screen our proposed chemical structures of evaluation of anticancer activity. Using the docking software, depending on the energy values we have to identify the best drug analogues that have great binding efficiency towards targets. Several modifications have to be made to the probable functional groups which are interacting with receptor molecules. Analogues of the drug molecules are prepared using ACD chemsketch and docking. Starting material, (2-Amino Pyrimidine) is a potent anticancer drug. The Pyrimidine and its various derivatives have various pharmacological activities including anticancer, antitubercular, antibacterial and antimicrobial. These activities are confirmed in various research projects by using many evaluation factors viz., in-vitro and in-vivo evaluations. We have studied our drug on following targets by using computer-based drug designing approach i.e., MOLECULAR DOCKING by using Mcule dock software and further the activity is confirmed by the in-vitro anti-cancer study on human colon cancer cell line for the compound 4C by MTT assay technique.

Keywords: Insilco drug designing, anticancer activity, Chalcones, Michael adduct, Molecular docking, In-vitro anticancer activity.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More