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Abstract

SYNTHESIS, MOLECULAR DOCKING & EVALUATION OF ANTHELMINTIC ACTIVITY OF 2-(2-AMINO ETHYL)-1HBENZIMIDAZOLE DERIVATIVES

Katti S. A.*, Desai K. S. and Loharkar S. V.

ABSTRACT

A novel series of 2 (2-aminoethyl)-1H-Benzimidazole was synthesized. The molecular docking study of these compound was performed at the active site of the β tubulin receptor. The synthesized compounds were characterized by spectral analysis (IR, 1H NMR). The screening of synthesized compound for in-vitro anthelmintic activity was studied using albendazole as reference drug. All compounds have shown binding ability at the active site of receptor and posses anthelmintic activity comparable to albendazole.

Keywords: 2(2-aminoethyl)-1H-Benzimidazole, ? tubulin receptor, anthelmintic activity.


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