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Abstract

NOVEL LONG OCULAR RETENTIVE FORMULATION DEVELOPMENT OF MICONAZOLE OPHTHALMIC SUSPENSION WITH HELP OF POLYMER PLATFORM SYSTEM

Simta Jadhav*, Kavita Vikram Inamdar and Dr. Milind J. Bhitre

ABSTRACT

Instilled ophthalmic formulations may not be completely available for eliciting therapeutic action because of various reasons such as rapid tear drainage, blinking of eye, lower residence time of ophthalmic formulation in eye and lower cul-de sac volume. The objective of present work was to develop long retentive miconazole ophthalmic suspension based on polymer platform system of carbopol 974 P and xanthan gum which was pre-identified by means of experimental design study. Carbopol 974 P and xanthan gum were used as gelling agent. The developed formulations were characterized for homogeneity, pH, particle size, viscosity, osmolality, rheology study, mucoadhesive strength, contact angle, assay of miconazole and benzalkonium chloride, degradation product, in vitro drug release, eye irritation test and pharmacodynamic efficacy study. A stable long retentive miconazole ophthalmic formulation was developed based on principles of quality by design and as per industrial standards.

Keywords: Polymer, ocular long retentive, miconazole, ophthalmic suspension.


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