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Abstract

FORMULATION AND EVALUATION OF ETHOSOMAL GEL OF DICLOFENAC SODIUM AND CAPSAICIN

Komal Gupta*

ABSTRACT

Ethosomes are ethanolic liposomes. Ethosomes are drug delivery carriers that are noninvasive and causes the drugs to transfer to the deep layers of skin and/or the systemic circulation. These are composed mainly of phospholipids such as phosphatidylcholine (PC), phosphatidyl serine (PS) and phosphatidic acid, high concentration of ethanol and water. The aim of the study was to improve the transdermal penetration of diclofenac sodium, poorly soluble drug. The purpose of the work was to formulate the vesicular carrier of combination of Diclofenac Sodium; an anti-inflammatory drug and Capsaicin; a powerful counterirritant in the form of ethosomes using phospholipids. The prepared ethosomes were characterized for vesicular size distribution, vesicular shape and surface morphology, percent entrapment efficiency, drug excipient compatibility study and zeta potential. Topical gels were prepared by cold method using carbopol 934 and ethosomal suspensions were incorporated into carbopol gel. The ethosomal gels were evaluated for pH, drug content, viscosity and in vitro drug permeation studies. The release profile was evaluated using release studies of different developed ethosomal formulations and comparison with available brands in markets. Results revealed that ethosome formulations can act as drug reservoir in the skin and extend the pharmacologic effects of diclofenac sodium.

Keywords: ethosomes, ethanol, vesicular, entrapment efficiency, pharmacologic, viscosity.


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