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Abstract

A CASE OF BILATERAL ANOPHTALMIA COMBINED WITH UNILATERAL CLEFT LIPS AND CLEFT PALATE

MIRAY Louis de Gonzague*, RAMANANIRINA Mirana Zita, RAKOTOMAHEFA Narison Mbolanirina, RANDRIANARIVELO Harinarivo Prosper, RAOBELA Léa

ABSTRACT

Anophthalmia (complete absence of eyes) and microphthalmia (small eyes) are two of the more common of the severe, disabling congenital anomalies of the eye. Many infants with anophthalmia or microphthalmia will have a coexisting defect involving non-eye structures or other eye structures. Pathogenesis of anophthalmia/microphthalmia is a complex interplay of single gene mutation, chromosomal anomalies, and environmental factors. We reported a one week old male who was born of a full-term by normal spontaneous delivery at 37 weeks of amenorhea from non-consanguineous parents (25 years & 18 years) and was their firstborn. The mother of the baby smoked and chewed tobacco, consumed alcohool, and use decoction and herbal medicine. The ophtalmological examination showed a bilateral empty orbits with an inflamed palpebral conjunctiva and purulent secretions. Besides, the baby presented a clift lips associated with clift palate. The main etiology of this deformity was not known because neither antenatal nor postnatal screenings were performed in order to elucidate the causes. We adressed some suggestions to avoid the repetition of this preventable malformation.

Keywords: Anophtalmie, cleft lips, cleft palate, smoking, herbal medicine.


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