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Murugavel R.*, Veerasivaraman M., Manjari V., Anbarasan B., Thanigainathan A.


Evaluation of toxicity is important before starting clinical trial of any drug. Need for traditional medicines have been increasing in the recent past, so it is necessary to ensure that the medicine prescribed are safe. Aim of the study is to evaluate the safety profile of Rasa Karpoora Kuligai (RKK) through Acute Oral Toxicity study and 28-Day Repeated Dose Oral Toxicity Study as per OECD guidelines. In Acute study, Animals were divided into 3 groups. Group I served as a control and treated with water. The remaining two groups were treated with 300mg/kg.b.wt and 2000mg/kg.bwt of Rasa Karpoora Kuligai orally. Animals were observed for toxic signs for 14 days and gross pathology was performed at the end of the study. In repeated dose toxicity study, the animals were divided into four groups. The first group was treated as control and second, third, fourth groups were treated with Low dose 230mg/kg/ b.wt, Mid dose 450mg/kg/b.wt, High dose 600mg/ kg/ b.wt of Rasakarpoorakuligai. In acute oral toxicity study, no treatment related death or toxic signs were observed. The 28-day repeated dose study did not show evidence of any significant treatment related changes in all observations from low dose to the high dose level, when compared with the control. Histopathological examination also revealed that no abnormalities. This study ensures the safety of the drug.

Keywords: Rasakarpoorakuligai, Toxicity, OECD guidelines.

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