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Abstract

FORMULATION AND OPTIMIZATION OF DELAYED RELEASE TABLET CONTAINING DOXYCYCLINE HYCLATE

Ritesh R. Dode* and Chetan M. Jain

ABSTRACT

Doxycycline hyclate act by broad spectrum antibacterial agent belonging to chemical class of tetracycline derivative. In this research paper various enteric coating polymers are used in formulation to attained delayed release of drug. Tablet formulation was prepared by using various excipients and delayed release polymers and their evaluation test are performed. Nine formulation trial batches were prepared by using Minitab 18 32 full factorial design. In that three formulation level (High, Medium and Low) of delayed release polymer as a factor and dissolution and drug content as an response were taken. From all nine batches batch F3 were selected as an optimized batch because of %Cumulative drug release and drug content were found satisfactory. Batch F3 gives results of % CDR (95.16%) and % drug content (101.25 %) having the concentration of 21.63 mg and 64.88 mg of HPMC K100M and Ethyl cellulose respectively and hence batch F3 was selected as an optimized batch.

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