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Dr. R. Ganesan*, Dr. S. Muthu Subramaniam, Jasno Saji John and Sruthimol V.


Background: Toxic epidermal Necrolysis (TEN) is an adverse reaction that can be induced by various drugs; the associated mortality rate is 20–25%. Paracetamol is widely used as an over-the-counter analgesic and antipyretic drug. It’s a remarkably safe drug devoid of serious side effects in therapeutic doses; Paracetamol is very rarely implicated to be a culprit of TEN. Case Prsentation: We report a case of 29 years old male presented with complaints of bilateral lower limb swelling and itching with blisters and scaling of skin all over the body after taking Paracetamol. Skin biopsy was consistent with toxic epidermal necrolysis. The patient was initiated with Cyclosporin and supportive treatment was given, to which he responded very well. Conclusion: clinicians must be more cautious while prescribing and should monitor patients for severe drug reactions, including TEN. Patients should also be educated regarding the adverse effects of NSAIDs.

Keywords: Toxic epidermal necrolysis, Paracetamol, Adverse reaction.

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