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Abstract

FORMULATION AND EVALUATION OF TELMISARTAN TABLETS EMPLOYING SOLVENT DEPOSITED SYSTEMS

K. Bhargavi, P. Hima Bindu and Dr. K. Ravi Shankar*

ABSTRACT

Telmisartan, a widely prescribed anti-hypertensive drug belongs to class II under BCS classification and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Because of poor aqueous solubility and dissolution rate it poses challenging problems in its tablet formulation development. The objective of the present study is to enhance the dissolution rate and dissolution efficiency of Telmisartan, a BCS class II drug by using solvent deposited systems. Solvent deposited systems of telmisartan in 1:5 drug: carrier ratio were prepared by solvent evaporation method. Telmisartan (40 mg) tablets were prepared employing its solvent deposited systems by direct compression method. All tablets prepared by employing solvent deposited systems fulfilled the official (IP2014) disintegration time specification of uncoated tablets. The correlation coefficient (r) values were higher in the first order model than in zero order model indicating that the dissolution of Telmisartan followed first order kinetics. Telmisartan dissolution was very rapid from the tablets formulated employing solvent deposited systems when compared to those formulated using telmisartan pure drug (F1). All the dissolution parameters (PD10, DE30, and K1) indicated rapid dissolution of telmisartan from tablets prepared by using solvent deposited systems. All the dissolution parameters (PD10, DE30, and K1) indicated rapid dissolution of Telmisartan from tablets prepared by employing solvent deposited systems. The order of increasing dissolution rate (K1) of Telmisartan observed with various tablet formulations was F4 > F6 > F5 > F3 > F2 > F1.. All the tablets except formulation F1 fulfilled the official dissolution requirement of NLT 75% drug dissolution in 30 min (IP 2014). Telmisartan tablets containing Solvent deposited systems of Pearlitol Flash (F4) gave higher dissolution rate (K1) of Telmisartan when compared with other formulations. Hence solvent deposited systems of Telmisartan in Pearlitol Flash is recommended for formulation of Telmisartan tablets with fast dissolution characteristics

Keywords: Solvent Deposited Systems, Telmisartan, Dissolution Rate, Dissolution Efficiency.


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