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Abstract

EFFICACY OF Β-BLOCKERS IN CONGESTIVE HEART FAILURE

Mahdi Abdulhadi Al Muammar*, Angham Ghazi Alghidany, Abdullah Hassan AL Muntashiri, Matuq Abdulrahman Zamzama, Mesfer Hamed Alghamdi, Saud Musaab Aldughaither, Alaa Ahmed Alsaegh and Jamal Suliman Alabdli

ABSTRACT

Background & Purpose: Beta blocking drugs have been proven to lessen the danger of hospitalization and demise in patients with slight-to-moderate congestive heart failure, but little is understood about the efficacy or protection of these drugs in excessive heart failure. The Aim of this work is to provide cumulative data about the effect of β- Blockers on morbidity and mortality outcomes in Congestive Heart Failure (CHF) patients. Methods: A systematic search was performed of PubMed, Cochrane library Ovid, Scopus & Google scholar to identify family medicine RCTs, clinical trials, and comparative studies, which studied the outcome of Β-blocker group versus Placebo group of CHF patients. A meta-analysis was done using fixed and random-effect methods. The primary outcome was mortality rate (of any cause). Secondary outcome was hospital admission due to CHF. Results: A total of 5 studies were identified involving 12785 patients, 6402 patients in Β-blocker group, and 6343 patients in Placebo group. Regarding outcome measured, meta-analysis study showed that, highly significant increase in mortality and hospitalization for CHF in placebo group as compared to B blocker group, with a combined risk ratio (RR) of 1.4 and 1.35 respectively (P < 0.01). Conclusion: To conclude, the beta blockers proved to be very effective in lowering mortality and the need for hospital admission due to HF patients.

Keywords: B Blockers, CHF.


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