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Abstract

CUBOSOMES – AN ADVANCED DRUG DELIVERY SYSTEM – A REVIEW

Shrikant Rajaram Divekar* and Dr. Vaibhav R. Vaidya

ABSTRACT

Cubosomes are the square and rounded particles with internal cubic lattices visible. Cubosomes are self-assembled nanostructured particles shaped by aqueous lipid and surface-active agent systems. Cubosomes are thermodynamically stable; they have a structure like “honeycombed” with bicontinuous domains of water and lipid in which surfactant assembles into bilayers and twisted into a three dimension, periodic, and least surface, forming a tightly packed structure. They exhibit totally {different|completely different} internal cuboidal structure and composition with different drug-loading modalities. Overall, cubosome have nice potential in drug nanoformulations for malignant melanoma treatment because of their potential benefits, as well as high drug payloads thanks to high internal area and isometric crystalline structures, comparatively easy preparation methodology, biodegradability of lipids, the ability of encapsulating hydrophobic, hydrophilic and amphiphilic substances, targeting and controlled release of bioactive agents. Cubosome dispersions are bioadhesive and biocompatible. Because of their properties, cubosome are versatile systems, administrable in different ways such as orally, percutaneously and parenterally. Cubosome structure by means of electron microscopy, “light scattering”, x-ray and “NMR”, nevertheless few researchers have been studying the potential of cubosome as “delivery systems”. Hydrating a surface-active agent or polar lipid that forms cuboidal section and then dispersing a solid like section into smaller particles typically forms a cubosomes. Such novel particles are used to encapsulate guest molecules that are either hydrophilic, lipophilic or amphiphilic, due to the compartmentalization of its structure.

Keywords: Cubosomes, honeycombed, versatile, drug payloads, compartmentalization.


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