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Abstract

STUDIES ON ADIPOSE –DERIVED STEM CELLS AS TREATMENT OF MUSCULAR DYSTROPHY INDUCED IN RATS

Afaf H. Kamel*, Rokaya H. Shalaby and Rana M. Adel

ABSTRACT

Duchenne muscular dystrophy is a dangerous, X-linked musclewasting illness induced through lack in the dystrophin gene. Statins are the mainly substantially drugs used for treating hypercholesterolemia. In contrast, the major bad effect of statins was myopathy. So the aims to induce muscular dystrophy in male rats by simvastatin, and to assess the regenerative capacity of adipose-derived stem cells (ADSCs) on skeletal muscles after induction of the disease. The present study was accomplished on a total number of 40 male albino rats, were divided into 2 main groups, the control group and the Muscular Dystrophy Group, which received 80 mg/kg b.wt./day as oral doses of SIMVACOR® for 46 days. In day 47, this group was subdivided into: Subgroup 1 which sacrificed in the same day, Subgroup 2 that was injected by ADSCs in day 47 and dissected after 14 days of receiving stem cells therapy, Subgroup 3 that was injected by ADSCs and dissected after 30 day. Animals were subjected to estimation of levels of serum creatine kinase (CK), total proteins (TP), calcium (Ca), chromosomal aberrations % and caveolin-3 gene expression. When compared to the control group, animals of subgroup 1 which received simvastatin only showed a significant elevation in serum CK, no significant increase in serum TP, Ca levels and in total CAs % while a significant decrease in Cav-3 gene expression. However, subgroup 2 and 3 which injected with stem cells, showed great extentnoticeable improvements on the level of serum, gene expression.

Keywords: Adipose-derived stem cells, Muscular dystroph, statins, simvastatin.


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