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Abstract

META-ANALYSIS: MYOPIA IN PATIENTS WITH OPEN-ANGLE GLAUCOMA

Jumanah Jameel Homsi*, Omar Khalid Alsaawi, Dai Samran Almutairi, Najlaa Samran Almutairi and Malak Khalid G. Alkuwaykibi

ABSTRACT

Background & Purpose: Myopia is a risk factor for open-angle glaucoma that could complicate both the diagnosis and treatment of glaucomatous disorder. presently, there may be a growing prevalence of myopia in lots of regions of the world. The Aim of this work is to provide cumulative data about the effect of myopia as a risk factor for Open-Angle Glaucoma (OAG). Methods: A systematic search was performed of PubMed, Cochrane library Ovid, Scopus & Google scholar to identify Ophthalmology RCTs, clinical trials, and comparative studies, which studied the outcome of OAG group versus Control group of patients. A meta-analysis was done using fixed and random-effect methods. The primary outcome was the rate any myopia. Secondary outcomes were high and low myopia rates. Results: A total of 5 studies were identified involving 20578 eyes with 5627 eyes in OAG group, and 14951 eyes in Control group. Regarding primary outcome measures, the fixed-effects model of the meta-analysis study showed highly significant increase in all myopia in OAG group compared to Control group (p < 0.01). Regarding secondary outcome measures, the fixed-effects model of the meta-analysis study showed significant increase in high myopia in OAG group compared to Control group (p = 0.025). The fixed-effects model of the meta-analysis study showed highly significant increase in low myopia in OAG group compared to Control group (p < 0.01). Conclusion: To conclude, myopia become associated with an increased occurrence of all forms of open-angle glaucoma and OHTN (ocular hypertension).

Keywords: Myopia, Open-Angle Glaucoma.


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