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Abstract

LIQUISOLID TECHNIQUE: A NOVEL APPROCH TO ENHANCE SOLUBILITY

Nagamani H. B.*, Ganesh N. S. and Vineeth Chandy

ABSTRACT

liquisolid system also termed as powder solution technology is a new promising and effective technique that can change the dissolution properties of poorly water-soluble drugs. Poorly water-soluble drugs are converted into dry looking, non adherent, free flowing and acceptably compressible powder by incorporating into suitable nonvolatile solvents, carrier and coating material. The obtained free flowing powder then subjected to preformulation studies like fourier transformed infrared spectroscopy, differential scanning Calorimetry for compatibility studies, flow properties, solubility studies, etc. These free-flowing powders are compressed into tablet or filled in capsules. The enhancement of solubility involves the mechanism of increase in wettability and surface of drug available for dissolution. This method is viable for industrial production, also useful in control and sustained drug delivery system. Hence due to above reasons liquisolid technique is most efficient and novel approach for solubility enhancement.

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