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Abstract

EVALUATION OF ANALGESIC ACTIVITY OF NAAGA SANGU PARPAM IN SWISS ALBINO MICE BY EDDY’S HOT PLATE METHOD

Kingsley J.*, Murugavel R., Anbarasan B., Uthrapathi S. and Sivakkumar S.

ABSTRACT

To evaluate analgesic activity of herbal formulation Naaga Sangu Parpam and compare it with pentazocine by using Eddy’s hot plate in mice. The animals were divided into 4 groups of six animals in each group. Group I received ghee (vehicle control). Group II animals received 10 mg/kg/i.p of pentazocine. Group III and group IV received Naaga Sangu parpam 13mg/kgb.wt and 26mg/kg b.wt respectively. In Eddy‟s hot plate method, Naaga Sangu Parpam showed analgesic activity 180 minutes after drug administration with mean pain tolerance time of 4.08±0.38 seconds while pentazocine showed analgesic activity at 180 minutes with pain tolerance time 5.5±0.6. Naaga Sangu Parpam at the dose of 26 mg/kg exhibits significant (p<0.001) analgesic activity.

Keywords: Naaga Sangu Parpam, Eddy’s hot plate, Pentazocine.


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