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Abstract

A NOVEL VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IVERCITIN AND ALBENDAZOLE IN BULK AND TABLET COMBINED DOSAGE FORMS

Muggu. Muralikrishna*, M. Lakshmi Surekha, R. Padma and Ch. Ajay

ABSTRACT

The present work deals with the development of a precise, accurate, simple, specific, reliable and less time consuming RP-HPLC method for the estimation of Ivercimectin and Albendazole tablets. The chromatographic separation was achieved on a Inertsil C18 ODS(4.6 x water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was carried out by using PDA detector at 290 nm. Ambient column temperature has maintained. The total run time was 10mins.The retention time of Ivercimectin and Albendazole were found to be 2.9 min. and 3.5 min. respectively. The performance of the method was validated according to the present ICH guidelines.

Keywords: RP-HPLC, Ivercimectin and Albendazole, Inertsil C18 ODS.


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