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Abstract

PHARMACEUTICAL FORMULATION & EVALUATION OF HERBAL MYRISTICA FRAGRANS CREAM FOR ATOPIC DERMATITIS

Shammika P.*, Jaseera O. T., Hanoof and P. V. Shakeer

ABSTRACT

Objective: The current study deals with the formulation and evaluation of herbal extracted Myristica fragrans cream for atopic dermatitis. Methods: The herbal Myristica fragrans was processed, phytochemically screened, analytically determined and extracted by ethanol cold maceration technique. The extracted Myristica volatile oil was formulated by melting and mixing the oil-aqueous phase containing lanolin as base, liquid paraffin, glyceryl monostearate, propylene glycol, triethanolamine and glycerine at different concentrations. The formulated herbal cream was evaluated for homogeneity, pH, washability, spreadability and carried out the invitro drug release, in-vitro anti-inflammatory study & anti-microbial study. Stability study has been conducted for the optimized formulation at temperatures 40 ± 2°C at 75 ± 5%. relative humidity. Results: The formulated herbal cream had showed good clarity, homogeneity, odour, spreadability and washability. It also has shown an increase in the drug release with a slight increase in the in-vitro antiinflammatory activity than compared to marketed drug. The optimum formulation selected was M2 which follows a zero order kinetics with Fickian diffusion phenomenon. The formulation found to be stable with no signs of phase separation and change in color. Conclusion: It can be concluded that herbal myristica fragrans creams having anti-bacterial and anti-inflammatory property can be used as provision of a barrier to protect the skin from atopic dermatitis.

Keywords: Myristica fragrans, cold maceration, in-vitro drug release, in-vitro antiinflammatory.


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