WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

VALIDATED UPLC/Q-TOF-MS METHOD FOR STRUCTURAL IDENTIFICATION AND QUANTITATIVE DETERMINATION OF ANTIHYPERTENSIVE DRUGS

Hamid Khan*

ABSTRACT

In the presented work the ultra-performance liquid chromatographic/quadrupole time-of-flight mass spectrometric (UPLC/Q-TOF-MS) method has been developed for Structural Identification and Quantitative Determination of Antihypertensive Drugs such as Losartan, Telmisartan, Valsartan Candesartan and Irbesartan,. For identification of drugs, the Q-TOF mass spectrometer was operated in negative ionization mode and quantification was done using the MS/MS transitions at m/z 421.2 to 127.00 for Losartan, m/z 513.18 to 469.13 for telmisartan, m/z 435.02 to 157.00 for valsartan, m/z 439.1 to 309.9 for Candesartan and m/z 427.2 to 193.08 for Irbesartan. The chromatographic separation was achieved on Acquity UPLCTM BEH C18 (100.0 × 2.1 mm, 1.7μm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50:50, v/v) at a flow rate of 0.25 mL/min. The calibration curves were linear over the concentration range of 1-1000 ng/mL for all the drugs. The developed method was validated according to ICH guidelines. The method is helpful in Structural Identification and Quantitative Determination of Antihypertensive Drugs.

Keywords: UPLC/Q-TOF-MS, Antihypertensive Drugs, Structural Identification.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More