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Abstract

FORMULATION AND EVALUATION OF ATENOLOL BUCCAL PATCHES BY USING, CAESALPINIA POLYMER AND TAMARIND POLYMER FOR THE TREATMENT OF HYPERTENSION

Chaithanya A. P.*, Soji S., Amina Ishana, Ayshath Mahsana Yajifa, Kadeeja Ruwaidah, Mohammed Adhil and Mohammed Nabeel

ABSTRACT

The present investigation involves formulation and evaluation of buccal patch of Atenolol, an antihypertensive drug to bypass the first pass metabolism. The buccal patch of Atenolol was prepared by solvent casting technique. Four formulation were prepared with varying concentrations of bioadhesive polymers like Hydroxy propyl methyl cellulose K-100M, Caesalpinia polymer and Tamarind polymer. Solvent ethanol was used with propylene glycol as plasticizer and Sucrose as sweetening agent. Drug-polymer interaction was investigated using FTIR. The prepared patches were evaluated for thickness, Surface pH, drug content uniformity, Ex vivo Mucoadhesive strength, % swelling index, folding endurance and in vitro drug release, Determination of Residence Time, Ex Vivo Permeation Study which produced satisfactory results with low standard deviation. After evaluation of all parameter, on the basis of results obtained batch T2 and C1 were found to be optimize batches. This batch shows controlled Drug Release after 8 hrs and best fitted in Higuchi model for drug release kinetic.

Keywords: Mucoadhesive, Atenolol, Drug delivery, Natural polymer.


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