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P.B.V. Siva Prasad*, C. Haranath, C.Surya Prakash Reddy, Dr. C. Sowmya.


In recent times, various developed and developing countries move towards combination therapy for treatment of multiple diseases and disorders requiring long term therapy. Combination therapy have various advantages over mono therapy such as problem of dose dependent side effects is minimized, a low dose combination of two different agents reduces the dose related risk, the addition of one agent may potentiate effects of other agent. In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bi-layer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bi-layer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. Several pharmaceutical companies are currently developing bi-layer tablets. This article explains about types of bi-layer tablets, potential reasons for considering bi-layer dosage form, challenges related to bi-layer tablet technology and about various bi-layer tablet press.

Keywords: Combination therapy, Bi-layer tablet, Bi-layer tablet press.

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