WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DESIGN DEVELOPMENT AND IN-VITRO EVALUATION CONTROLLED RELEASE TABLETS

Divya Sahu*, Dr. Arun Patel, Prof. Shailendra Patel and Prof. Neelesh Dwivedi

ABSTRACT

The present investigation was aimed at designing controlled release matrix tablets of isradipine, (C19H21N3O5) using various natural polymers like guar gum, karaya gum, xanthan gum and veegum, individually and in combinations of various concentrations, to produce controlled release of isradipine in order to improve the efficacy and patient compliance and to compare the drug release profiles of optimized formulation and commercial formulation by similarity and difference factors. The drug release from the formulation was found to be zero order. Using Higuchi's model and the Korsmeyer equation, the drug release mechanism from the controlled release tablets was found to be Anomalous (non-Fickian) diffusion. The values of difference factor, f1 and similarity factor, f2 was found to be 1.74 and 63.38 indicating similarity between drug release profiles of optimized formulation and reference product.

Keywords: Buccal delivery, Isradipine, Mucoadhesion, First pass metabolism, Permeation Enhancers.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More