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Abstract

META-ANALYSIS: EFFECT OF VITAMIN D DEFICIENCY ON COGNITIVE FUNCTIONS AND DEMENTIA

Ebtihal Mohammed Masrahi*, Abdulrahman Ahmed Mohammed Medawi, Sultanah Hamoud Alruwaili, Turki Faissal Bugshan, mawadah Mohammed Jannah, Ibrahim Ayed Alqahtani, Bashayer Abdullah Al Zayed

ABSTRACT

Background & Purpose: Low vitamin D status has also received attention as an ability metabolic risk factor for dementia. a number of researches have proven that a low serum vitamin D concentration was associated with an increased hazard of dementia and Alzheimer’s disorder in older adults. The Aim of this work is to provide cumulative data about the efficacy and safety of vitamin d deficiency on cognitive functions and dementia. Methods: A systematic search was performed of PubMed, Cochrane library Ovid, Scopus & Google scholar to identify Neurology RCTs, clinical trials, and comparative studies, which studied the outcome of Vitamin D deficiency group (<50 nmol/L), versus Normal Vitamin D group of patients. A meta-analysis was done using fixed and random-effect methods. The primary outcome of interest was cognitive state assessed by Mini-Mental State (MMSE score). Secondary outcome was the prevalence of dementia. Results: A total of 6 studies were identified involving 8636 patients, with 2805 patients in Vitamin D deficiency group, and 5831patients in Normal Vitamin D group. Regarding primary outcome measure, the random-effects model of the meta-analysis study showed significant decrease in mean MMSE score in Vitamin D deficiency group compared to Normal Vitamin D group (p = 0.017). Regarding secondary outcome measure, the fixed-effects model of the meta-analysis study showed highly significant increase in rate of dementia in Vitamin D deficiency group compared to Normal Vitamin D group (p < 0.01). Conclusion: To conclude, lower vitamin D concentrations are related to poorer cognitive function and a higher danger of AD.

Keywords: Vitamin D Deficiency, Cognitive Functions, Dementia.


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