ALCOHOL INDUCED OXIDATIVE STRESS AND HEPATOTOXICITY- A REVIEW
Renu Malik*, Dr. K. G. Singhal and Ritu
ABSTRACT
This article is based on the various advances in mechanism of
hepatotoxicity by alcohol. Liver is mostly target for various drugs,
xenobiotics because of its unique metabolism. Alcohol metabolism in
liver generates the various reactive oxygen species (ROS). These
radicals lead to cell apoptosis by enhancing the production of kupffer
cells and neutrofill infiltration. Kupffer cells trigger the release of
cytokines, reactive oxygen species and chemokines, TNF-α. Alcohol
depletes fatty acid oxidation and induces lipogenesis. This article also
summarizes the molecular level of liver damage including PPAR,
Adiponectin, SIRT1, SERBPs. Liver have wide range of metabolic enzymes which is use to
metabolize alcohol specially CYT P450. CYP2E1 mediates ethanol oxidation reaction by two
different kind of oxidation, which is elaborated here.
Keywords: Alcohol, Oxidative stress, Hepatosis, Cirrhosis, CYT P450, Adeponectin.
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