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Abstract

SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF PIOGLITAZONE AND GLIMEPIRIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING ABSORBANCE RATIO METHOD

Tejaswini Kande*, Pallavi Dhekale, Supriya Khatal and Priyanka Borude

ABSTRACT

Glimepiride and Pioglitazone in combination are available as tablet dosage forms in the ratio of 2: 15. A simple, reproducible and efficient spectrophotometric method has been developed for the simultaneous estimation of Glimepiride and Pioglitazone in bulk and tablet dosage forms. The sampling wavelengths selected are 227 nm and 235 nm, Absorption Ratio Method, the sampling wavelengths selected are 251 nm (iso-absorptivity wavelength) and 235 nm.

Keywords: Pioglitazone, Glimepiride, UV-Visible Spectrophotometric, Validation.


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