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Abstract

A REVIEW ON ANALYATICAL METHODS FOR ESTIMATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN BULK AND IN PHARMACEUTICAL DOSAGE FORM BY HPLC METHODS

*Yogesh B. Mali, Mairal Pooja B. and Dr. Ambadas R. Rote

ABSTRACT

Dapagliflozin and Saxagliptin are very effectively used treatment for type II diabetes. They are very potent inhibitor of renal glucose reabsorption and dipeptidyl peptidase protein 4 and sodium glucose transport protein 2 and also they are called as DPP4 & SGLT2 inhibitors. They are generally administered as tablets. Determination of Dapagliflozin and Saxagliptin in pharmaceutical dosage form and bulk form, several analyatical methods including UV, HPLC, LC-MS, HPTLC techniques has been developed. Method indicaticating human plasma stability and impurity profiling are also describe for both drugs. For qualitative and quantitative estimation of Dapagliflozin and Saxagliptin these analytical method can be used and it can also be used for its related degradants in bulk formulations and biological fluids.

Keywords: Dapagliflozin, Saxagliptin, RP-HPLC.


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