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Abstract

DESIGN AND OPTIMIZATION OF IMMEDIATE RELEASE TABLETS OF EFAVIRENZ USING MICRO CRYSTALLINE CELLULOSE

Ch. Sunil Kumar*, R. B. Desireddy, S. Mounika, S. K Basheera and S. K. Siddabee

ABSTRACT

The goal of any drug delivery system is to provide a therapeutic amount of drug in the proper site in the body to achieve promptly and then to maintain the desired drug concentration. That is, the drug delivery system should deliver drug at a rate dedicated by the needs of the body over a specified period of treatment. Drug delivery systems (DDS) are a strategic tool for expanding markets/indications, extending product life cycles and generating opportunities. Oral administration is the most popular route for systemic effects due to its case of ingestion, pain, avoidance, versatility and most importantly patient compliance. In these solid formulations do not require sterile conditions and are these for less expensive to manufacture. Immediate release tablets are designed to disintegrate and release their medication with no special rate controlling features such as special coating and other techniques. Efavirenz being discussed is under Non-Nucleoside Reverse transcriptase inhibitor (NNRTI) used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1.

Keywords: Efavirenz, HIV, NNRTI, DDS, HAART.


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