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Shubhangi Darekar*, Dr. Vijaya Barge and Dr. Ashok Bhosale


The oral cavity is an attractive site for the delivery of many drugs. The oral route has been most convenient and commonly employed route of drug delivery. Through this route it is possible to realize the mucosal (local effect) and transmucosal (systemic effect) drug administration. In first case the main aim is to achieve the site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrier to reach the systemic circulation. The main obstacles is that drug meet when administered via the buccal route derive from the limited absorption area and the barrier properties of the mucosa. Oral films provide better drug utilization in by-passing the first pass metabolism, enhance drug bioavailability, mask the bitter taste of drugs and do not need water to swallow. In this article main focus is done on overview of Buccal drug delivery, anatomy of oral mucosa, different dosage forms, formulation aspects, evaluation methods, packaging; this will be useful to circumvent the difficulties associated with the formulation design.

Keywords: Buccal drug delivery, Transmucosal, Oral mucosa, Innovative, Mucoadhesion, Barrier, Permeability.

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