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Abstract

NOVEL APPROACH FOR DESIGN AND CHARACTERIZATION OF MUCOADHESIVE BUCCAL GANCICLOVIR IN SITU GEL

Ch. N.V.S. Mastanrao*, R. B. Desireddy, D. Vasavi Latha, G.L.S. Mounika, G. Ramya Sadhana and K.L.T. Sowjanya

ABSTRACT

The present study was to designed to prepare periodontal gel of ganciclovir for the treatment of inflammation conditions. In this studyit was found that as the phospholipid concentration was increased, it resulted in corresponding increase in the entrapment efficiency of reconstituted liposomes. In conclusion, a sustained delivery of ganciclovir can be achieved by proliposomal drug delivery system. Phospolipids, being the major component of liposomal system, can easily get integrated with the skin lipids and maintain the desired hydtation conditions to improve drug permeation. Fusion of lipid vesicles with skin ontributed to the permeation enhancement effect. Invitro studies concluded the enhance skin permeation and retention of Ganciclovir was observed and was due to liposolubilized state of drugs with in proliposomes which helped to produce the deport effect. The prepared proliposomes are incorporated into gel. The data show that liposomal systems can make the drug molecules more accessible with in skin layers. The conclusion compares favourably with early study showed that drug associated with liposomes bilayer bounds and better routed into skin. Other studies have shown that liposomal ambience may help modify the permimeability characteristics of the stratum corneum, and the system keep the drug molecules with in skin layers so that sustain release of drug can be achieved. The results advocate the extension of this worh on the preliminary clinical trails and commercialization of proliposomal gel formulation of antiviral drugs for effective buccal pharmacotherapy in treatment of virus.

Keywords: Gancivlovir, Proliposomal gel.


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