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Abstract

EVALUATION OF ANALGESIC ACTIVITY OF GANDHAGA SARKKARAI IN SWISS ALBINO MICE BY EDDY’S HOT PLATE METHOD

Arunkumar G.*, Anbarasan B., Murugavel R., Uthrapathi S. and Visweswaran S.

ABSTRACT

To evaluate analgesic activity of herbal formulation Gandhaga Sarkkarai and compare it with pentazocine by using Eddy’s hot plate in mice. The animals were divided into 4 groups of six animals in each group. Group I served as control and did not receive any drug. Group II animals received 10 mg/kg/i.p of pentazocine. Group III and group IV received Gandhaga Sarkkarai 100mg/kgb.wt and 400mg/kg b.wt respectively. In Eddy‟s hot plate method, Gandhaga Sarkkarai showed analgesic activity 180 minutes after drug administration with mean pain tolerance time of 4.08±0.38 seconds while pentazocine showed analgesic activity at 180 minutes with pain tolerance time 5.5±0.6. Gandhaga Sarkkarai at the dose of 26 mg/kg exhibits significant (p<0.001) analgesic activity.

Keywords: Gandhaga Sarkkarai, Eddy’s hot plate, Pentazocine.


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