FORMULATION AND EVALUATION OF HERBAL GEL FOR ANTIARTHRITIC ACTIVITY
Mohammad Rizwan Ul Haque*, Sakshi R. Yadav, Dr. Dinesh M. Biyani, Dr. G. S. Bhoyar and Dr. Milind J. Umekar
ABSTRACT
The aim of present investigation was to evaluate anti-rheumatic
activity of two herbs (Commiphora mukul and Boswellia serrata) and
to formulate a topical gel dosage form. Boswellia serrata dry extract
65% was collected from the Konark Herbals and Health Care and
Commiphora mukul dry resin was collected from Local Market,
Nagpur. The evaluation of crude drug and the re-successive solvent
extraction of resin was carried out. Development of gel was done by
using carbapol 934 and PEG 400. From the result of preliminary
phytochemical screening of extract, it was observed that the fractional
product of Commiphora mukul resin contained triterpenoids and
sterols. The result obtained from present work indicated that the entire
drug was uniformly distributed and there was no precipitation in
formulation. It was observed that the formulation was stable at
different temperatures and exhibit good percentage spread by weight that would assure the
skin application. From the present work, it was concluded that it is possible to formulate the
herbal gel for anti-arthritic activity by using Commiphora mukul and Boswellia serrata. The
results showed that the content of Gel components had significant effect on their physical,
rheological and in vitro drug release characterization.
Keywords: Rheumatoid arthritis, commiphora mukul, boswellia serrata, herbal gel, resins, joint pain.
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