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Abstract

TO STUDY THE SAFETY AND EFFICACY OF SGLT2 INHIBITORS AND OTHER ORAL HYPOGLYCAEMIC AGENTS WITH INSULIN IN UNCONTROLLED TYPE 2 DM

*Pooja Chandran, Anu Chacko, Arul Prakasham, Aswin P. Raj and Archana M. Nair

ABSTRACT

Diabetic mellitus is a major health care problem of India. Evidence shows that prevalence of diabetes is increasing in both urban and rural areas. Patients with diabetes have twice the risk for death than those without diabetes. With increase in prevalence of uncontrolled type 2 diabetics, newer class of ant diabetic agents such as Sodium Glucose Co transporter 2 (SGLT-2) inhibitors were introduced which has more benefits when used in combination with insulin in uncontrolled type 2 diabetic patients. Aim: To study the safety and efficacy of SGLT 2 inhibitors and other oral hypoglycaemic agents with insulin in uncontrolled type2 DM. Methodology: The study is a prospective observational study. The study population include the inpatients and Outpatients in the Department of General Medicine and Department of Endocrinology in a Teritiary Care Hospital. The total sample size recruited was 120 and divided into two different treatment groups so that each group consist of 60 patients. The study has obtained ethical clearance from institutional ethical committee. Result: Patients reported significantly greater reduction in HbA1c (0.0012) and FBC (0.0056) values in SGLT2 add on therapy versus other oral hypoglycaemic agents. Moreover important in the secondary outcome was also directionally and statically significantly greater in the group 1 versus group 2 as assessed under the study protocol; weight (0.0052) and BMI (0.0108). In blood pressure the systolic blood pressure (0.0789) and diastolic blood pressure (0.351) was statistically not significant. Conclusion: The SGLT -2 Inhibitors are safe and effective in the treatment of Uncontrolled Type 2 DM. It has a better glycemic control and has additional benefits like weight, BMI and BP reduction. These ensure the benefit of SGLT – 2 Inhibitors with insulin as compared to other Oral Hypoglycaemic agents with insulin in uncontrolled type2 DM.

Keywords: SGLT2, DM, Insulin.


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