Abstract

EVALUATION OF THE USE OF PROTON PUMP INHIBITORS AND H2 RECEPTOR BLOCKERS IN INPATIENT DEPARTMENT OF DISTRICT HEADQUARTERS HOSPITAL, TIRUPPUR

Husain P. M. Pharm., Akhil Satheesh M. Pharm., Dr. R. Senthilselvi M. Pharm, Ph.D.*, S. Rajarajan M Pharm., Dr. V. Ganesan M Pharm, Ph.D., Dr. Divya A., MBBS, D.P.M.

ABSTRACT

H2 – receptor antagonists like Ranitidine, which is the first-choice H2 – receptor antagonist in most patients. Proton pump inhibitors (PPIs) like Omeprazole produce profound gastric acid suppression and are the most effective treatment for gastro - esophageal reflux disease. PPIs are also effective short-term treatments for gastric and duodenal ulcers. Inappropriate use of antisecretory agents can cause many problems in patients so the appropriateness of antisecretory agents is the main objective of the present study, which should be accordance to standard treatment guidelines. This study is a hospital based prospective and observational study conducted at multispecialty teaching hospital over a period of 10 months. Patients of age 18 years and above who were on antisecretory drugs prescription and willing to give consent were included in the study. Out of 154 patients enrolled in the study, it was observed that Ranitidine in 124 (72.1%) followed by Omeprazole 48 (27.9%). Different combinations are used. Ranitidine injection given to 80 (64.51%) where as Ranitidine tablet is 44 (35.48). Out of 154 patients prescribed with antisecretory medications the average cost of treatment was for Ranitidine injection (Rs.30.975) followed by Omeprazole (Rs.23.903) and Ranitidine tablet (Rs.6.443). Our study highlights the need of rational drug use practices like prescribing by generics, drugs under essential drug list and stop orders for certain PPI drugs. Continuing education about rational drug use, awareness about the misuse of drugs and development of easy to use treatment guidelines for common diseases in General Medicine Department is recommended.

Keywords: Antisecretory Drugs, PPIs, H2 receptor blockers, Rational Use.