WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITIES OF NOVEL HYDRAZONE DERIVATIVES

Navitha Alupula*, Ramgopal Appani, V. Alagarsamy and B. Babu Rao

ABSTRACT

A new series of Hydrazone derivatives(IIIa-IIIm) were obtained by synthesizing 2-(benzamido) benzohydrazide with different aromatic and heterocyclic aldehydes. These derivatives are characterized by FTIR, 1H-NMR, 13C-NMR and Mass spectra. The synthesized derivatives were screened for their in vitro antibacterial activity against Klebsella Pneumoniae, Salmonella Paratyphi, Escherischia Coli, Basillus Substilis where IIIc, IIIe compounds showed significant activity against Klebsella Pneumoniae. IIIa-IIIj compounds were screened for their in vitroantifungal activity against fungal spores like Aspergillus Nigrum, Aspergillus Clavatus, Penicillium Notatum and Colleotrichem Coffeanum where IIIa, IIIe compounds showed significant activity against Aspergillus Nigrum. IIIa, IIIl, IIIm compounds were screened for analgesic activity among these IIIm compound showed significant activity. In vitrocytotoxic activity of IIIb compoundshowed significant cytotoxic activity against all the five cell lines tested in the region of 9, 23, 33, 26, 17μm for CEM, L1210, Molt 4/C8, HL60 & BEL 7402 respectively.

Keywords: Klebsella Pneumoniae, Salmonella Paratyphi, Escherischia Coli.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More