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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITIES OF NOVEL HYDRAZONE DERIVATIVES

Navitha Alupula*, Ramgopal Appani, V. Alagarsamy and B. Babu Rao

ABSTRACT

A new series of Hydrazone derivatives(IIIa-IIIm) were obtained by synthesizing 2-(benzamido) benzohydrazide with different aromatic and heterocyclic aldehydes. These derivatives are characterized by FTIR, 1H-NMR, 13C-NMR and Mass spectra. The synthesized derivatives were screened for their in vitro antibacterial activity against Klebsella Pneumoniae, Salmonella Paratyphi, Escherischia Coli, Basillus Substilis where IIIc, IIIe compounds showed significant activity against Klebsella Pneumoniae. IIIa-IIIj compounds were screened for their in vitroantifungal activity against fungal spores like Aspergillus Nigrum, Aspergillus Clavatus, Penicillium Notatum and Colleotrichem Coffeanum where IIIa, IIIe compounds showed significant activity against Aspergillus Nigrum. IIIa, IIIl, IIIm compounds were screened for analgesic activity among these IIIm compound showed significant activity. In vitrocytotoxic activity of IIIb compoundshowed significant cytotoxic activity against all the five cell lines tested in the region of 9, 23, 33, 26, 17μm for CEM, L1210, Molt 4/C8, HL60 & BEL 7402 respectively.

Keywords: Klebsella Pneumoniae, Salmonella Paratyphi, Escherischia Coli.

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