DESIGN, SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITIES OF NOVEL HYDRAZONE DERIVATIVES
Navitha Alupula*, Ramgopal Appani, V. Alagarsamy and B. Babu Rao
ABSTRACT
A new series of Hydrazone derivatives(IIIa-IIIm) were obtained by
synthesizing 2-(benzamido) benzohydrazide with different aromatic
and heterocyclic aldehydes. These derivatives are characterized by FTIR,
1H-NMR, 13C-NMR and Mass spectra. The synthesized derivatives
were screened for their in vitro antibacterial activity against Klebsella
Pneumoniae, Salmonella Paratyphi, Escherischia Coli, Basillus
Substilis where IIIc, IIIe compounds showed significant activity
against Klebsella Pneumoniae. IIIa-IIIj compounds were screened for
their in vitroantifungal activity against fungal spores like Aspergillus
Nigrum, Aspergillus Clavatus, Penicillium Notatum and Colleotrichem
Coffeanum where IIIa, IIIe compounds showed significant activity
against Aspergillus Nigrum. IIIa, IIIl, IIIm compounds were screened for analgesic activity
among these IIIm compound showed significant activity. In vitrocytotoxic activity of IIIb
compoundshowed significant cytotoxic activity against all the five cell lines tested in the
region of 9, 23, 33, 26, 17μm for CEM, L1210, Molt 4/C8, HL60 & BEL 7402 respectively.
Keywords: Klebsella Pneumoniae, Salmonella Paratyphi, Escherischia Coli.
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