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Abstract

IN-VITRO QUALITY ANALYSIS OF DIFFERENT BRANDS OF PARACETAMOL TABLET AVAILABLE IN BANGLADESH

Md. Giash Uddin, Mahmuda Ferdous, Md. Arafat Jakir, Md. Shalahuddin Millat, Shafayet Ahmed Siddiqui, Mohammad Safiqul Islam and Mohammad Sarowar Uddin*

ABSTRACT

Paracetamol is the most prescribed analgesic drug which is used in the treatment of mild to moderate pain relief. The aim of the present study is to examine the physio-chemical parameters of commercially available local brands of paracetamol tablets in Bangladesh. Five brands of paracetamol tablet were explored by testing various parameters according to in-vitro analytical methods. The study parameters were weight variation, friability, disintegration, dissolution and hardness. All brands were tested according to their pharmacopoeia claimed methods to find out their qualities. The requirements of weight variation and friability value were compiled for all brands. According to the BP/IP recommendation for uncoated tablets, fifteen minutes of disintegration time was also complied for all the brands. All brands demonstrated not less than 80% drug release in 45 minute as per BP and not less than 85% in 30 minute as per IP. In case of weight variation, content of each brand was found to be within the range of 95– 105%. The hardness of all the brands was found to be in the range of 40-80 N. Again, all brands of paracetamol exhibited less than 1% friability. The findings of the present study suggest that every paracetamol brands which are available in Bangladeshi market supporting the IP/BP requirements. Therefore, as an over-the-counter drug, the consumption of paracetamol is safe and effective for human consumption.

Keywords: Paracetamol; wet variation; hardness; friability; disintegration time; dissolution profile.


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