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Abstract

ANTIULCEROGENIC ACTIVITY OF CORNSILK EXTRACT OF ZEA MAYS

Jude E. Okokon*, Bassey A. L. and Utibe A. Edem

ABSTRACT

Cornsilk of Zea mays is used in Ibibio traditional medicine for the treatment of various ailments including diabetes mellitus, malaria and gastrointestinal disorders. Objective: To investigate the antiulcerogenic potential of cornsilk extract of Zea mays. Materials and Methods: Ethanol cornsilk extract of Zea mays (170-510 mg/kg) was evaluated for antiulcerogenic activity against indomethacin, ethanol and histamine-induced ulcers in rats. Results: The cornsilk extract was found to possess significant (p<0.05) activity against indomethacin-induced ulcer. The effects of the extract against ethanol and histamine was not significant (p>0.05) and non dose-dependent. Conclusion: These results suggest that the cornsilk extract of Zea mays possess antiulcerogenic potential which are due to the activities of the phytochemical constituents.

Keywords: Zea mays, cornsilk, antiulcer.


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