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Abstract

COMPARATIVE HYPOGLYCEMIC EFFECT OF CUMINUM CYMINUM AND GINGIBER OFFICINALE ON DIABETIC MICE

Priti Kumari*, Sunil Kumar Choudhary, Ashok Ghosh, Arun Kumar, Md. Ali, Ranjit Kumar

ABSTRACT

Diabetes is the world’s oldest disease, described in historical records of civilizations such as those found in ancient Egypt, Persia, and India (Holt, 2004). The incidence of diabetes is rapidly increasing in world at alarming rate. High blood glucose levels over time can causes damage of blood vessels, resulting in serious health complications such as high blood pressure, heart disease, stroke, blindness, kidney failure, and amputations. Cumin is the most common flavouring agent in India. Cumin has been used as anti-inflammatory, diuretic, carminative, and antispasmodic, in the treatment of toothaches and epilepsy and also as an aid for treating dyspepsia, jaundice, diarrhea, flatulence, and indigestion. Ginger is a strong antioxidant substance and may either mitigate or prevent generation of free radicals and also very useful in cases of ulcerogenesis due to its antioxidant activities. In the present study, diabetic mice were treated with Cuminum cyminum and Zingiber officinale whereas Diabetic control group were treated with distilled water for 16 weeks. Diabetic mice were treated with Cuminum cyminum @ 80 mg/kg body weight and with Zingiber officinale @ 80 mg/kg body weight for 16 weeks. The treatment with Zingiber officinale restored glucose level up to 106 mg/dl while the glucose level was up to 123 mg/dl in Cuminum cyminum administered mice group. Uric acid and SGPT were effectively restored by 16 weeks’ administration of Cuminum cyminum. Hepatic cells were also observed in restored condition in Cuminum cyminum administered group. It is concluded from the study that Cuminum cyminum restored glucose level LFT and KFT effectively in diabetic mice. It also restored hepatic cells and sinusoid effectively, while Zingiber Officinale restored glucose and urea levels effectively. Uric acid and SGPT level were not restored effectively in ginger administered mice group. The present study suggests that Cuminum cyminum acts effectively on LFT/ KFT and histology of liver of diabetic mice in comparison to Zingiber Officinale administered group.

Keywords: LFT, KFT, Sinusoid, diuretic, dyspepsia.


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