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Ashwini S. Nagpure*, Bharati V. Bakade, Pravin K. Bhoyar, Rupali D. Deshmukh*


A basic objective of present work is to optimize the delivery of medication so as to achieve a measure of control of therapeutic effect in the face of uncertain fluctuation in the in vivo environment in which drug release takes place. Quitiapine Fumarate is antipsychotic drug which is use in the psychotic disease. Quetiapine Fumarate is one of the emerging short acting drugs, so developed formulation provides the advantage of sustained release formulation. The polymers like HPMC K100, HPMC K15, K4M were utilized in the formulation of microspheres containing Quetiapine Fumarate and evaluated for its drug release characteristics This production process is based on the solubility behaviour of HPMC, which is poorly soluble in water. Addition of an acid improves its solubility as a result of protonation of amino groups. HPMC solubility is also affected by other anions present in the solution. In the presence of phosphate, polyphosphate and sulphate ions, HPMC shows a decreased solubility. The formulation was optimised on the basis of physical characteristics, Drug release, particle size, angle of repose. In vitro drug release was carried out in phosphate buffer 7.4 and HCL 0.1N. Among all the formulations, F8 with shows 97.4% better controlled release at the end of 12 hrs. It has been found that the optimized formula F8 containing of HPMC K100 as drug retarding polymers shows better sustained effect for by other polymers.

Keywords: Quetiapine Fumarate, Microspheres, Microencapsulation, SEM.

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