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Abstract

COMPARATIVE STUDY ON EFFECT OF HERBAL DILUENTS ON RELEASE OF DRUG

Rina Maskare*, Nitin Indurwade, Pratima Yelekar and Indrapal Pahade

ABSTRACT

The main objective of this research was to introduce and evaluate disintegrant property of natural excipients like Potato starch and Maize starch in tablet formulation. Pharmaceutical excipients developed from natural sources are economic. Potato starch and Maize starch were prepared and physicochemical properties like solubility, iodine test, angle of repose, bulk density, tapped density, carr‟s index, hausner‟s ratio and melting point were evaluated. The interaction between the excipcents and Paracetamol was also studied through FTIR spectroscopy. Tablets were then prepared by direct compression method using different disintegrants and the disintegration time of the tablets formulated was determined. Dissolution study was conducted to characterize release mechanism from the tablet system and data were fitted to various kinetic models. It was found that tablets with potato starch and maize starch disintegrate more rapidly than the tablets with microcrystalline cellulose. The prepared formulations were passed the evaluation test that is weight variation, hardness, friability and content uniformity. The mechanism of drug release from tablets was found to be non-Fickian, anomalous transport. Results from various evaluations suggested that potato starch and maize starch could be used as disintegrants in tablet formulation.

Keywords: Potato starch, Maize starch, Natural excipients, Disintegrant, Paracetamol.


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