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Abstract

HAVE GLYCYRRHIZA GLABRA & COLCHICINE CYTOTOXIC EFFECT ON PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA

Faruk H. Al- Jawad, Nahi Y. Yaseen, Haitham M. Kadhim* and Inssaf I. Hussein

ABSTRACT

Background: Chronic myelogenous leukemia is a malignant clonal, myeloproliferative disorder of the pluripotent hematopoietic stem cells. the objective to evaluate in vitro the cytotoxic effect of both glycyrrhiza globra (licorice) and colchicne on normal myeloid stem cell & leukemic myeloid cells of patients with chronic myelogenous leukemia. The serial dilution of aqueous licorice extraction & colchine in the concentration (250,125,68.5,31.25,15.625,7.8,25 μg/ml) were added to the cell culture. Cells viability was assessed by MTT assay. Results: The obtained results shamed that the toxic effect (inhibitory rate of growth) of both licorice & colchicines urea in dose e and time dependent. There were significant difference (P<0.05) between concentration & time exposure (24, 48,72hr). the highest inhibition rate of licorice & colchicines on the leukemic cells were 75.50% & 75.16% respectively in concentration 250 μg/ml & the loment inhibition rate were 40.49% & 43.74% respecters in concentration 7.8125 μg/ml for exposure time 72 hr while the highest inhibition rate of licorice & colchicines on the normal myeloid cell were 41.82% 837.22% respectively in concentration 250μg/ml & the lowest inhibition rate were 13.17% & 17.21% respectively in concentration 7.8125 μg/ml for exposure time 72hr. conclusion both licorice & colchicines have potent growth inhibition for leukemia myeloid cells & less inhibition for normal cells.

Keywords: Glycyrrhiza globra-licorice, colchicine, normal & leukemic myeloid cells culture.


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