Abstract

REVIEW ON ALZHEIMER DISEASE AND THE IMPLEMENTED PHARMACEUTICAL APPROACHES

Shadi Fathi Taha, Zhou Jiangping*, Ahmed Alfatih Sirelkhatim Fadul and Omer Mohamed Omer Ahmed

ABSTRACT

Alzheimer's disease was considered a huge health burden for scientists for many generations and is one of the biggest health problems for humanity. Since its discovery in 1906 by Alosi Alzheimer, drug delivery have being the major obstacle. With the presence of a selective membrane barrier allowing certain molecules to enter and exit, delivering drugs to the brain was considered a challenge but now, new cutting edge technologies have been developed allowing scientists to construct nano sized particles from different materials to bypass the BBB. Nevertheless, peptides, ligands and coating materials were added for modification of the particle for better targeting abilities. The following review focuses on the nanotechnology used for targeting Alzheimer's disease and the pharmaceutical strategies for drug delivery to the brain as well as a few collections have been mentioned for the nano sized particle that has been used for drug delivery, eventually the future perspective will be discussed for better engaging the Alzheimer's disease.

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