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Abstract

DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET FORMULATION AND EVALUATION OF AMBROXOL HYDROCHLORIDE

Dr. S. Chandra*, S. Kavibharathi, M. Parthiban, R. Suresh, A. Sheik Alisha and B. Nandhini

ABSTRACT

Ambroxyl is a Mucolytic expectorant. Ambroxyl has short half life (3- 4hrs) makes the development of sustained release forms extremely advantageous, Ambroxyl is a weak acidic pka 4.5 – 6, it has pH dependent solubility, characterized in low pH condition present in stomach, Which consequently delayed in onset of action, Formulation of SR tablet is effective approach for mucolytic expectorant it gives maximum action with prolong drug concentration due to sustained release from tablet matrix. Different formulation (F1 – F7) designed with HPMC K100, HPMC 5CPS, Povidone K30, MCCP. pre and post -compression parameters for all formulation were studied. Batch F7 selected as optimized batch on the basis of dissolution profile.

Keywords: Ambroxy, HPMC, MCCP, Dissolution, Sustained release.


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