World Journal of Pharmaceutical Research (WJPR) has indexed with various reputed international bodies like : Index Copernicus , Google Scholar , EBSCO Publishing Inc (Academic Search Complete), USA , Indian Science Publications , Urlich's Periodicals Directory, Proquest, UK , NewJour-Georgetown University Library, USA , SOCOLAR, China , eGranary Digital Library, USA , CAS (A Division of American Chemical Society) USA , Research Bible, Fuchu, Tokyo. JAPAN , Science Central, USA , Kaohsiung Medical University Library, CHINA , VIKAS PSOAR (Pharmaceutical Sciences Open Access Resources) , Scopus ((Elsevier Products in process) , EMBASE (Elsevier Products, in process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , Thomson Reuters, USA (in process) , Genamics JournalSeek (In Process) , Hinari Research , Geneva Foundation for Medical Education and Research, Switzerland (In Process) , Lupton Library, (In Process) , Polish Scholarly Bibliography , Virtual Library Pharmacy, Medicine and Health, Biosciences , UDLedge Science Citation Index , Global Impact Factor (0.652) , International Impact Factor Services , Directory of Research Journal Indexing (DRJI) , Universal Impact Factor (0.9861) , International Scientific Indexing, UAE , SJIF Impact Factor (5.045) , Scholar Steer, (Under Process) , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , InfoBase Index (In Process) , Scholar Article Impact Factor, SAIF , CiteFactor , Journal Index (JI, Under Process) , Indian citation Index (ICI) , Indian Citation Index (ICI) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Eurasian Scientific Journals Index (ESJI) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Journalseek Database , Pubmed Database [NLM ID:101644668] (Under Process) , IP Indexing (Under Process) , EBSCO, USA , Web of Science Group (Under Process) , Directory of Research Journals Indexing ,

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	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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Dr. Muhammad Baqir MR Fakhrildin
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Abstract

DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET FORMULATION AND EVALUATION OF AMBROXOL HYDROCHLORIDE

Dr. S. Chandra*, S. Kavibharathi, M. Parthiban, R. Suresh, A. Sheik Alisha and B. Nandhini

ABSTRACT

Ambroxyl is a Mucolytic expectorant. Ambroxyl has short half life (3- 4hrs) makes the development of sustained release forms extremely advantageous, Ambroxyl is a weak acidic pka 4.5 – 6, it has pH dependent solubility, characterized in low pH condition present in stomach, Which consequently delayed in onset of action, Formulation of SR tablet is effective approach for mucolytic expectorant it gives maximum action with prolong drug concentration due to sustained release from tablet matrix. Different formulation (F1 – F7) designed with HPMC K100, HPMC 5CPS, Povidone K30, MCCP. pre and post -compression parameters for all formulation were studied. Batch F7 selected as optimized batch on the basis of dissolution profile.

Keywords: Ambroxy, HPMC, MCCP, Dissolution, Sustained release.

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Abstract

DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET FORMULATION AND EVALUATION OF AMBROXOL HYDROCHLORIDE

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