DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET FORMULATION AND EVALUATION OF AMBROXOL HYDROCHLORIDE
Dr. S. Chandra*, S. Kavibharathi, M. Parthiban, R. Suresh, A. Sheik Alisha and B. Nandhini
ABSTRACT
Ambroxyl is a Mucolytic expectorant. Ambroxyl has short half life (3-
4hrs) makes the development of sustained release forms extremely
advantageous, Ambroxyl is a weak acidic pka 4.5 – 6, it has pH
dependent solubility, characterized in low pH condition present in
stomach, Which consequently delayed in onset of action, Formulation
of SR tablet is effective approach for mucolytic expectorant it gives
maximum action with prolong drug concentration due to sustained
release from tablet matrix. Different formulation (F1 – F7) designed
with HPMC K100, HPMC 5CPS, Povidone K30, MCCP. pre and post -compression
parameters for all formulation were studied. Batch F7 selected as optimized batch on the
basis of dissolution profile.
Keywords: Ambroxy, HPMC, MCCP, Dissolution, Sustained release.
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