ROLE OF YASTIMADHU GHRITA PRATISARANA IN MANAGEMENT OF ORAL CANCER
*Dr. Ravindra Bhati, Dr. Manindra Kumar Vyas and Dr. Monika Das
ABSTRACT
Oral cancer is the Sixth most common malignancy in the world.
According to World Health Organization there are an estimated 6,
57,000 new cases of cancers of the oral cavity and pharynx each year,
and more than 3, 33,000 deaths. The prevalent oral habits of use
tobacco products like Cigarette, Pan masala, excessive intake of
alcoholic beverages, poor oral hygiene, prolonged focal irritation from
teeth and dentures, HPV (human papilloma virus) infection. One of the
very common side effects of Radiation/Chemotherapy especially of the
head and neck malignancies is mucositis, which makes eating difficult.
According to Ayurveda, 65 varieties of oral diseases can arise in seven
anatomic locations. Ayurveda recommends some daily use therapeutic
procedures for the prevention of and maintenance of oral health. These include: Pratisarana,
Dhavani (Brushing), Jivha Lekhana (Tongue scrapping) and Gandoosha (gargling) or oil
pulling and tissue regeneration therapies. Some of the scientifically proven beneficial effects
of these procedures are Pratisarana with Yashtimadhu Ghrita significantly reduced intensity
of radiation and chemotherapy induced mucositis. Yastimadhu has madhura rasa, sheeta
virya, madhura vipaka and is vata-pitta shamaka property. Yastimadhu has vrana shodhana
and vrana ropana properties that help for healing of the wound of oral cancer. Ghrita has a
soothing property and form a thin film layer over them and that allows early epitheliazation
of wound. Yastimadhu is anti-ulcerogenic and anti-inflammatory in property. Licochalcone A
is a flavonoid found in liquorice root (Glycyrrhiza glabra). It is known for anti-microbial
activity and reported ability to inhibit cancer cell proliferation. Glycyrrhetinic acid has
proved to have anti-inflammatory effect similar to glucocorticoid and mineralocorticoids.
Keywords: Licochalcone A, Vrana, Mucositis, Regeneration.
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