Abstract

ROLE OF YASTIMADHU GHRITA PRATISARANA IN MANAGEMENT OF ORAL CANCER

*Dr. Ravindra Bhati, Dr. Manindra Kumar Vyas and Dr. Monika Das

ABSTRACT

Oral cancer is the Sixth most common malignancy in the world. According to World Health Organization there are an estimated 6, 57,000 new cases of cancers of the oral cavity and pharynx each year, and more than 3, 33,000 deaths. The prevalent oral habits of use tobacco products like Cigarette, Pan masala, excessive intake of alcoholic beverages, poor oral hygiene, prolonged focal irritation from teeth and dentures, HPV (human papilloma virus) infection. One of the very common side effects of Radiation/Chemotherapy especially of the head and neck malignancies is mucositis, which makes eating difficult. According to Ayurveda, 65 varieties of oral diseases can arise in seven anatomic locations. Ayurveda recommends some daily use therapeutic procedures for the prevention of and maintenance of oral health. These include: Pratisarana, Dhavani (Brushing), Jivha Lekhana (Tongue scrapping) and Gandoosha (gargling) or oil pulling and tissue regeneration therapies. Some of the scientifically proven beneficial effects of these procedures are Pratisarana with Yashtimadhu Ghrita significantly reduced intensity of radiation and chemotherapy induced mucositis. Yastimadhu has madhura rasa, sheeta virya, madhura vipaka and is vata-pitta shamaka property. Yastimadhu has vrana shodhana and vrana ropana properties that help for healing of the wound of oral cancer. Ghrita has a soothing property and form a thin film layer over them and that allows early epitheliazation of wound. Yastimadhu is anti-ulcerogenic and anti-inflammatory in property. Licochalcone A is a flavonoid found in liquorice root (Glycyrrhiza glabra). It is known for anti-microbial activity and reported ability to inhibit cancer cell proliferation. Glycyrrhetinic acid has proved to have anti-inflammatory effect similar to glucocorticoid and mineralocorticoids.

Keywords: Licochalcone A, Vrana, Mucositis, Regeneration.