MUCOSITIS IN CANCER PATIENTS TREATMENT AND MANAGEMENT
Kumutha T.*, Akshaya Sreenivasan, Bitson Augustine, Jibin Jacob Chacko, T. Shivakumar
ABSTRACT
Purpose: The aim of this study was to update the clinical practice
guidelines for the use of basic oral care, prevention and/or treatment of
oral mucositis (OM). Methods: A literature search was made of the
PubMed, Medline, Science Direct, Google, Cochrane and Scopus
databases, using different combinations of the following key words:
―oral mucositis‖, ―treatment‖, ―prevention‖, ―management‖,
―chemotherapy‖. Unfortunately, there is not a single method which is
capable of preventing or eliminating OM in an efficient way. the
articles where searched from 2000 -2019. The present study offers a
literature review of all the articles published over the last 19 years
referred to the prevention and/or treatment of oral mucositis. Results: A total of 28 papers
were identified within the scope of this section, out of which 20 were analyzed with reviewed
studies. A new Suggestion was made for oral glutamine for the prevention of OM in head and
neck (H&N) cancer patients receiving radiotherapy with concomitant chemotherapy. In this
article, we reviewed new therapeutic methods of OM including cryotherapy, honey and
coffee, propolis, low-level laser therapy, growth factors, stem cell therapy, hyaluronic acidbased
substances. Conclusion: OM is almost an inevitable negative repercussion of CT, RT,
and radiochemotherapy. Proper prophylaxis and management may prevent the intensity of
OM and eventually leads to a better disease control.
Keywords: .
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