A REVIEW ON ESTIMATION OF CLOPIDOGREL AND ASPIRIN IN BULK AND IN PHARMACEUTICAL DOSAGE FORM
Dhanshri R. Shinde*, Dr. R. B. Laware, Dr. S. B. Dighe and Ankita V. Deodhe
ABSTRACT
Platelet activation and aggregation are considered to be central to
arterial thrombus formation. Antiplatelet therapy is therefore important
for both the treatment and prevention of cardiovascular disease. The
literature has revealed that number of method have been published for
estimation and of clopidogrel and aspirin like RP-HPLC,
Spectrophotometric (UV), UPLC, etc. These methods were reported
for analysis. The review gives information of development and
validation of clopidogrel and aspirin in bulk and pharmaceutical
dosage form and validation as per ICH guidelines. thise is a fixed drug
combination available in these generation. These drugs are compatible
with other antiplatelate drug which having same or equal potency and
less side effect.
Keywords: Clopidogrel, aspirin, analytical method.
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