Abstract

A REVIEW ON ESTIMATION OF CLOPIDOGREL AND ASPIRIN IN BULK AND IN PHARMACEUTICAL DOSAGE FORM

Dhanshri R. Shinde*, Dr. R. B. Laware, Dr. S. B. Dighe and Ankita V. Deodhe

ABSTRACT

Platelet activation and aggregation are considered to be central to arterial thrombus formation. Antiplatelet therapy is therefore important for both the treatment and prevention of cardiovascular disease. The literature has revealed that number of method have been published for estimation and of clopidogrel and aspirin like RP-HPLC, Spectrophotometric (UV), UPLC, etc. These methods were reported for analysis. The review gives information of development and validation of clopidogrel and aspirin in bulk and pharmaceutical dosage form and validation as per ICH guidelines. thise is a fixed drug combination available in these generation. These drugs are compatible with other antiplatelate drug which having same or equal potency and less side effect.

Keywords: Clopidogrel, aspirin, analytical method.