REVIEW ON NOVEL APPROACHES FOR TARGETING DRUGS TO THE BRAIN
Shivraj Popat Jadhav*, Heena Salim Shah, Deepak Balasaheb Somvanshi, Ganesh Bhaskar Sonawane, Deepak Devidas Sonawane, Khanderao Rajaram Jadhav
ABSTRACT
Human Brain is very delicate organ and it act as vital controlling unit
of body and hence it is strictly protected by nature to shieldregular
brain function. Blood Brain Barrier [BBB] is among the main barriers
which restrict entry of different drugs into the brain. And because of
BBB it is more difficult to treat several diseases of brain like
Alzheimer’s disease, Parkinson’s diseases, dementia, mood disorders,
AIDS and several bacterial infections. Therefore it is necessary to
employ novel approaches for treatment of disease of brain. These
novel approaches will target brain in effective way. The current review
encompasses various barriers for delivery of drug into brain along with several novel
approaches which can be used for targeting drug to the brain like use of prodrug, use of
nanotechnology based products, by use of different carries like liposome, microspheres,
nanoemulsion, polymeric micelles and dendrimers.
Keywords: Brain, Blood Brain Barrier, Alzheimer’s disease, Nanoparticles, Liposomes.
[Full Text Article]