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Abstract

FORMULATION AND EVALUATION OF DILTIAZEM HCL BUCCAL PATCHES BY USING Lannea GUM

Dr. S. Chandra*, R. Suresh*, S. Mahendran, S. Kavibharathi, S. Sangeetha and A. Sheikalisha

ABSTRACT

The present investigation involves formulation and evaluation of buccal patch of Diltiazem Hydrochloridean calcium channel blocker drug to bypass the first pass metabolism. The buccal patch of Diltiazem Hydrochloride was prepared by solvent casting technique. Six formulation were prepared with concentrations of bioadhesive polymers like e.g Solvent acetone was used with cellulose acetate. Drug-polymer interaction was investigated using FTIR. The prepared patches were evaluated for thickness, Surface pH, drug content uniformity, Ex vivo Mucoadhesive strength, % swelling index, folding endurance and in vitro drug release, Determination of Residence Time, Ex Vivo Permeation Study which produced satisfactory results with low standard deviation. After evaluation of all parameter, on the basis of results obtained batch F6 as found to be a optimize batch. This batch shows 98.6% Controlled Drug Release after 6hrs and best fitted in Higuchi model for drug release kinetic.

Keywords: Mucoadhesive, Diltiazem Hydrochloride, Drug delivery, Controlled Drug Release, lannea Gum.


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