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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

FORMULATION AND EVALUATION OF DILTIAZEM HCL BUCCAL PATCHES BY USING Lannea GUM

Dr. S. Chandra*, R. Suresh*, S. Mahendran, S. Kavibharathi, S. Sangeetha and A. Sheikalisha

ABSTRACT

The present investigation involves formulation and evaluation of buccal patch of Diltiazem Hydrochloridean calcium channel blocker drug to bypass the first pass metabolism. The buccal patch of Diltiazem Hydrochloride was prepared by solvent casting technique. Six formulation were prepared with concentrations of bioadhesive polymers like e.g Solvent acetone was used with cellulose acetate. Drug-polymer interaction was investigated using FTIR. The prepared patches were evaluated for thickness, Surface pH, drug content uniformity, Ex vivo Mucoadhesive strength, % swelling index, folding endurance and in vitro drug release, Determination of Residence Time, Ex Vivo Permeation Study which produced satisfactory results with low standard deviation. After evaluation of all parameter, on the basis of results obtained batch F6 as found to be a optimize batch. This batch shows 98.6% Controlled Drug Release after 6hrs and best fitted in Higuchi model for drug release kinetic.

Keywords: Mucoadhesive, Diltiazem Hydrochloride, Drug delivery, Controlled Drug Release, lannea Gum.

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