FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESIVE BUCCAL PATCHES OF FUROSEMIDE
Km. Pratiksha*, Dr. Vikas Sharma, Lavkush Tiwari and Kris Jain
ABSTRACT
This study is mainly focused on the ability of polymer to polymer to
expand the bioavailability of Furosemide and to release the drug in
controlled foreordained way. The polymers selected for the study
include natural and synthetic polymer like Poly vinyl alcohol, Poly
vinyl pyrolidine, Propylene glycol and HPMC 15 based on their
physicochemical properties. The mucoadhesive buccal patches were
prepared by solvent casting method. The prepared patches were
subjected to physical evaluations, in vitro diffusion studies and
stability study. All the formulations have shown good adhesive
property, tensile strength, folding endurance, thickness, pH and moisture content. The
diffusion studies have shown that the percentage drug release is from natural polymer based
patches is more than the synthetic polymer with different polymer based mucoadhesive
patches. The In vitro drug release, evaluation, stability and accelerated stability studies of the
mucoadhesive patches shown that the formulation containing natural polymer has the
promising results with 100.71% drug release within 10 hours, folding endurance 301-319,
patch thickness 0.21-0.27 mm, surface pH 6.16-6.70, moisture content 1.73 to 2.91, tensile
strength 5.18 to 13.64 kg/mm2.
Keywords: Furosemide, Buccal patches, Mucoadhesive, In-vitro drug release.
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