Abstract

BIOMEDICAL ACTIVITY OF ZrO2 AGAINST ESCHERICHIA COLI ISOLATED FROM PREGNANT WOMEN WITH URINARY TRACT INFECTION

Dr. A. Mohankumar*, A. Chithira and S. Vijayalakshmi

ABSTRACT

Urinary tract infection (UTI) is one of the common bacterial infections during pregnancy. Its significance in pregnancy in view of its associated maternal and fetal morbidity and mortality has been widely evaluated. Colon infection caused by predominant organisms E.coli the most common pathogen in UTI and colon infections also serious troubles among pregnant women. So urine samples were collected from different clinics and Public Health Centre around rural area of Tirupur city. Totally 25 multidrug resistant E.coli was isolated from 17 mid stream urine samples and confirmed by using routine laboratory techniques. The isolates were subjected to four different antibiotic categories comprising 10 antibiotics. Strain No. MK04, MK08, MK09 and MK10 showed resistant against six antibiotics which showed 60% frequency followed by MK07 and MK05, showed resistant against five antibiotics which showed 50% frequency. Minimum resistant was recorded through the isolate MK01 showed 30% resistant against three antibiotics. Among 10 different antibiogram, 10 isolates showed multiple antibiotic resistant against the antibiotics tested. Currently, the metal oxide nanoparticles are the most promising tools applied as antimicrobial agents for human diseases. Different concentration of Zirconium oxide 50μl, 100μl and 150μl were used against Eschericia coli. In the present study metal oxide nanoparticles such as Zirconium oxide was used and it shows prominent antibacterial activity against UTI causing organism.

Keywords: UTIs, Pregnant women, Antimicrobial drug resistance, ZrO2.