BIOMEDICAL ACTIVITY OF ZrO2 AGAINST ESCHERICHIA COLI ISOLATED FROM PREGNANT WOMEN WITH URINARY TRACT INFECTION
Dr. A. Mohankumar*, A. Chithira and S. Vijayalakshmi
ABSTRACT
Urinary tract infection (UTI) is one of the common bacterial infections
during pregnancy. Its significance in pregnancy in view of its
associated maternal and fetal morbidity and mortality has been widely
evaluated. Colon infection caused by predominant organisms E.coli the
most common pathogen in UTI and colon infections also serious
troubles among pregnant women. So urine samples were collected
from different clinics and Public Health Centre around rural area of
Tirupur city. Totally 25 multidrug resistant E.coli was isolated from 17
mid stream urine samples and confirmed by using routine laboratory
techniques. The isolates were subjected to four different antibiotic
categories comprising 10 antibiotics. Strain No. MK04, MK08, MK09
and MK10 showed resistant against six antibiotics which showed 60%
frequency followed by MK07 and MK05, showed resistant against five
antibiotics which showed 50% frequency. Minimum resistant was recorded through the
isolate MK01 showed 30% resistant against three antibiotics. Among 10 different
antibiogram, 10 isolates showed multiple antibiotic resistant against the antibiotics tested.
Currently, the metal oxide nanoparticles are the most promising tools applied as antimicrobial
agents for human diseases. Different concentration of Zirconium oxide 50μl, 100μl and 150μl
were used against Eschericia coli. In the present study metal oxide nanoparticles such as
Zirconium oxide was used and it shows prominent antibacterial activity against UTI causing
organism.
Keywords: UTIs, Pregnant women, Antimicrobial drug resistance, ZrO2.
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