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Abstract

FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS BASED ON ONDANSETRON HYDROXY PROPYL-Β- CYCLODEXTRIN COMPLEXES

Nadir Khan*, Nitya Shanty, Alok Kumar, Robinsh Kumar and Vidhan Chand Bala

ABSTRACT

Orodispersible tablets (ODTs) containing Ondansetron (OND) Hydroxy Propyl –β- Cyclodextrin (HP-β - CD) were prepared by direct compression. The solubility of OND was enhanced by complexation with HP-β – CD by kneading method. The complex 1:1 molar ratio exhibited highest solubility was compressed into ODT. Crospovidone was used as a Superdisintegrant in the range of 2.5 to 10% w/w. The disintegration time of tablets of various batches was in the range of 60 to 80 seconds. The in vitro release study displayed faster and complete release of drug within 30 minutes. The prepared batches were compared with marketed orally disintegrating tablets. In the present study, ODT of Ondansetron containing HP-β- CD were prepared by direct compression using Superdisintegrant Crospovidone. 1:1 molar ratio was chosen and the complex was prepared by kneading method. The solubility of drug was found to be 0.018±0.005mg/ml and by complexing with HP-β-CD the solubility was increased up to 2.82±0.54mg/ml. Angle of repose, bulk density, tapped density; Carr’s index and hausner ratio all were in range according to the pharmacopoeia. Disintegration time was under the limit. The In vitro release was faster as compare to the marketed formulation.

Keywords: Orodispersible tablets, Ondansetron, Hydroxy propyl - ?- Cyclodextrin, inclusion complex, Superdisintegrant, solubility analysis.


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